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Sertraline or mirtazapine for depression in dementia

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Sertraline or mirtazapine for depression in dementia

Post  Admin on Tue Jul 19, 2011 7:43 pm

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

Results:
Decreases in depression scores did not differ between controls & participants allocated to receive sertraline or mirtazapine , or between participants in the mirtazapine and sertraline groups. Also adverse events were noted.

Interpretation:
Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.

Note: HTA-SDD= Health Technology Assessment Study of the Use of Antidepressants for Depression in Dementia.

Read the complete article at -->
The Lancet, Early Online Publication, 18 July 2011

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