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Sertraline or mirtazapine for depression in dementia

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Sertraline or mirtazapine for depression in dementia

Post  Admin on Tue Jul 19, 2011 7:43 pm

Sertraline or mirtazapine for depression in dementia (HTA-SADD): a randomised, multicentre, double-blind, placebo-controlled trial

Decreases in depression scores did not differ between controls & participants allocated to receive sertraline or mirtazapine , or between participants in the mirtazapine and sertraline groups. Also adverse events were noted.

Because of the absence of benefit compared with placebo and increased risk of adverse events, the present practice of use of these antidepressants, with usual care, for first-line treatment of depression in Alzheimer's disease should be reconsidered.

Note: HTA-SDD= Health Technology Assessment Study of the Use of Antidepressants for Depression in Dementia.

Read the complete article at -->
The Lancet, Early Online Publication, 18 July 2011

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