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Waist circumference is the best anthropometric predictor for insulin resistance in nondiabetic patients with schizophrenia treated with Clozapine.

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Waist circumference is the best anthropometric predictor for insulin resistance in nondiabetic patients with schizophrenia treated with Clozapine.

Post  Admin on Sun Jul 31, 2011 10:19 pm

Waist circumference is the best anthropometric predictor for insulin resistance in nondiabetic patients with schizophrenia treated with Clozapine but not Olanzapine.

Henderson DC, Fan X, Sharma B, Copeland PM, Borba CP, Freudenreich O, Cather C, Evins AE, Goff DC.
Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA


The goal of this study was to evaluate which anthropometric measure (human body measurement) best predicts insulin resistance measured by the insulin sensitivity index (SI) and the homeostasis model of assessment of insulin resistance (HOMA-IR) in nondiabetic patients with schizophrenia treated with clozapine or olanzapine.

In this study, Waist Circumference was the single best anthropometric surrogate for predicting IR in patients treated with clozapine but not olanzapine. The results suggest that WC may be a valuable screening tool for predicting IR in patients with schizophrenia being treated with clozapine who are at relatively higher risk of developing the metabolic syndrome, type 2 diabetes mellitus, and associated cardiovascular disease.

Read the complete article here:
NIH Public Access


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