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Acute Mania: Comparative Efficacy & Acceptability of Pharmacological Treatment

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Acute Mania: Comparative Efficacy & Acceptability of Pharmacological Treatment

Post  Admin on Wed Aug 17, 2011 11:48 pm

Acute Mania: Comparative Efficacy & Acceptability of Pharmacological Treatment


Meta-analysis published in Lancet 17 Aug, 2011:

68 randomised controlled trials (16 073 participants) were systematically from Jan 1, 1980, to Nov 25, 2010, which compared any of the following pharmacological drugs at therapeutic dose range for the treatment of acute mania in adults: aripiprazole, asenapine, carbamazepine, valproate, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, quetiapine, risperidone, topiramate, and ziprasidone.

The main outcomes were the mean change on mania rating scales and the number of patients who dropped out of the allocated treatment at 3 weeks. Analysis was done by intention to treat.

Interpretation
Haloperidol Tops the List
Overall, antipsychotic drugs were significantly more effective than mood stabilisers. Risperidone, olanzapine, and haloperidol should be considered as among the best of the available options for the treatment of manic episodes. These results should be considered in the development of clinical practice guidelines.

Read the full article here:
Lancet



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