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Efficacy and safety of Pregabalin Vs Lamotrigine for newly diagnosed Partial Seizures

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Efficacy and safety of Pregabalin Vs Lamotrigine for newly diagnosed Partial Seizures

Post  Admin on Tue Sep 06, 2011 8:56 pm

Efficacy and safety of Pregabalin Vs Lamotrigine in patients with newly diagnosed partial seizures

The Lancet Neurology, Early Online Publication, 1 September 2011


Efficacious and safe monotherapy options are needed for adult patients with newly diagnosed epilepsy. As an adjunctive treatment for partial seizures, pregabalin compares favourably with lamotrigine and is an effective, approved treatment.

This phase 3, double-blind, randomised, non-inferiority study compared the efficacy and tolerability of pregabalin and lamotrigine monotherapy in patients with newly diagnosed partial seizures at 105 centres, mostly in Europe and Asia.

Interpretation
Pregabalin has similar tolerability but seems to have inferior efficacy to lamotrigine for the treatment of newly diagnosed partial seizures in adults.

Read the full article here:
Lancet Neurology

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