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Early Coadministration of Clonazepam with Sertraline for Panic disorder

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Early Coadministration of Clonazepam with Sertraline for Panic disorder

Post  Admin on Sun Sep 25, 2011 2:55 pm

Early Coadministration of Clonazepam with Sertraline for Panic disorder

Arch Gen Psychiatry. 2001 Jul;58(7):681-6.

Although this medication combination is widely used in clinical practice, there is no well-tested, optimal method of coadministering these medications for the treatment of panic disorder.
The purpose of this study was to test the efficacy of early coadministration of clonazepam with sertraline in the treatment of panic disorder.

- Patients (N=50) were treated with flexible-dose, openlabel sertraline (target dose, 100 mg/d) for 12 weeks.
- In addition, for the first 4 weeks of the trial, patients were randomly assigned to receive either placebo clonazepam (n=26)
or active clonazepam (0.5 mg by mouth 3 times daily) (n=24),
- followed by 3 weeks of tapered doses
- After the tapering period, open-label sertraline treatment was continued through the end of the study.
- Patients did not receive cognitive behavioral therapy or any other psychotherapy at this time

An intent-to-treat analysis revealed a much greater proportion of responders in the sertraline/clonazepam compared with the sertraline/placebo group at the end of week 1 of the trial (41% vs 4%) (P=.003).
There was a significant between-group difference at the end of week 3 with 14 (63%) of 22 of the sertraline/clonazepam group responding to treatment vs 8 (32%) of 25 of the sertraline/placebo group (P =.05).

These data indicate that rapid stabilization of panic symptoms can be safely achieved with a sertraline/ clonazepam combination, supporting the clinical utility of this type of regimen for facilitating early improvement of panic symptoms relative to sertraline alone.

Read the full article here:
Archives of Gen Psychiatry

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