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Efficacy Among Second-Generation Antidepressants is About the Same

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Efficacy Among Second-Generation Antidepressants is About the Same

Post  Admin on Sat Jan 28, 2012 2:46 pm

Comparative Benefits and Harms of Second-Generation Antidepressants for Treating Major Depressive Disorder.
Ann Intern Med. 2011 Dec 6;155(11):772-85.




Background:
Second-generation antidepressants dominate the management of major depressive disorder (MDD),
but evidence on the comparative benefits and harms of these agents is contradictory.

Methods:
Meta-analyses and mixed-treatment comparisons of response to treatment and weighted mean differences were conducted on specific scales to rate depression.

Results:
- No clinically relevant differences in efficacy or effectiveness were detected for the treatment of acute, continuation, and maintenance phases of MDD.
- No differences in efficacy were seen in patients with accompanying symptoms or in subgroups based on age, sex, ethnicity, or comorbid conditions.
- Individual drugs differed in onset of action, adverse events, and some measures of health related quality of life.

Conclusion:
Current evidence does not warrant recommending a particular second-generation antidepressant on the basis of differences in efficacy. Differences in onset of action and adverse events may be considered when choosing a medication.

Full article (PDF) is available here:
http://www.annals.org/content/155/11/772.full.pdf+html




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