Follow Forum_Psych on Twitter
Search
 
 

Display results as :
 


Rechercher Advanced Search

Statistics
We have 222 registered users
The newest registered user is raheelmemon

Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Share

Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation

View previous topic View next topic Go down

Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation

Post  Admin on Sun Jul 15, 2012 7:17 pm

Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation: A Quantitative Review of Efficacy and Safety.
J Clin Psychiatry. 2007 Dec;68(12):1876-85.



OBJECTIVE:
To compare the efficacy and safety of the intramuscular formulations of Ziprasidone, Olanzapine, and Aripiprazole in treating agitation.

DATA EXTRACTION:
Number needed to treat (NNT) for response to treatment for agitation and number needed to harm (NNH) for extrapyramidal effects were calculated from the study reports. Additional safety outcomes subject to NNH analysis were obtained from product labeling.

RESULTS:
- Using the a prior definitions of response at 2 hours after the first injection, NNT for response versus placebo (or placebo equivalent) in treating agitation for the pooled data at the recommended dose of ziprasidone 10-20 mg was 3 (95% CI = 2 to 4), for olanzapine 10 mg was 3 (95% CI = 2 to 3), and for aripiprazole 9.75 mg was 5 (95% CI = 4 to 8 ).
- Treatment-emergent adverse events occurring during the pivotal trials revealed statistically significant NNH versus placebo (or placebo equivalent) for:
* Aripiprazole for headache (NNH = 20, 95% CI = 11 to 170) and nausea (NNH = 17, 95% CI = 11 to 38),
* for ziprasidone in the treatment of headache (NNH = 15, 95% CI = 8 to 703), and
* for olanzapine in treatment-emergent hypotension (NNH = 50, 95% CI = 30 to 154).
- Olanzapine and aripiprazole had a more favorable extrapyramidal side effect profile compared to haloperidol. (There was no haloperidol treatment arm in the ziprasidone studies.)


*****************
Click on to post your comments
avatar
Admin
Admin
Admin

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

http://psychiatry.find-forum.net

Back to top Go down

Re: Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation

Post  perox123 on Wed Sep 19, 2012 9:05 pm

great job for the graph!!!

perox123

Posts : 3
Points : 3
Reputation : 0
Join date : 2012-04-02

Back to top Go down

Re: Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation

Post  Admin on Wed Sep 19, 2012 9:09 pm

perox123 wrote:great job for the graph!!!

Thanks Perox123 !!

*****************
Click on to post your comments
avatar
Admin
Admin
Admin

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

http://psychiatry.find-forum.net

Back to top Go down

Re: Comparison of Intramuscular Ziprasidone, Olanzapine, or Aripiprazole for Agitation

Post  Sponsored content


Sponsored content


Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum