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Antidepressants use in Liver disease?

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Antidepressants use in Liver disease?

Post  Admin on Sat Sep 29, 2012 9:42 pm


Which antidepressant will you prefer in patient with liver disease/abnormal liver function test?

I don't have good source to answer this question.
Please contribute your experience and sources for this question.

Duloxetine (Cymbalta) is one that we should avoid (FDA warning).

Thanks


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Re: Antidepressants use in Liver disease?

Post  adisuper on Tue Oct 02, 2012 11:53 am

SSRI are the prefferd anti-depressants in liver disease.

Of the SSRIs, paroxetine prescribed at the lower end of the dose range seems to be the safest option. Citalopram in the lower dose range and fluoxetine at half the usual dose, or given on
alternate days, will have less sedative effects.
Sertraline and lofepramine are to be avoided
Advances in psychiatric treatment,Managing depression in physical illness,Siobhan MacHale,2002

MAO-I and nefazodone should be avoided

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Re: Antidepressants use in Liver disease?

Post  Admin on Thu Oct 04, 2012 8:13 pm


Thanks Adisuper

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Re: Antidepressants use in Liver disease?

Post  mentalist on Tue Jul 15, 2014 1:57 pm

Imipramine: start with 25 mg/day and titrate slowly (weekly at most) if required
or
Paroxetine or citalopram: start at 10 mg if severe hepatic impairment. Titrate
slowly (if required) as above (but note increased risk of bleeding)

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Re: Antidepressants use in Liver disease?

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