Follow Forum_Psych on Twitter
Search
 
 

Display results as :
 


Rechercher Advanced Search

Statistics
We have 222 registered users
The newest registered user is raheelmemon

Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Share

Clozapine Induced Eosinophilia: Neglected Important Adverse Effect

View previous topic View next topic Go down

Clozapine Induced Eosinophilia: Neglected Important Adverse Effect

Post  Admin on Wed May 11, 2016 7:38 pm

Clozapine Induced Eosinophilia: 
Neglected Important Adverse Effect

* Eosinophilia is a non dose dependent side-effect.
* Prevalence: ~1% of clozapine-treated patients.
* Onset: 1st year of treatment, mostly in the initial 4 weeks.
Course: transient course and spontaneous remission in most patients. 
* Note: In some cases it may predict subsequent neutropenia, myocarditis, eosinophilic colitis, pancreatitis and toxic hepatitis.
* Recommendations
(a) Interrupt Clozapine for absolute eosinophil count >4000/cu mm until the eosinophil count falls below 3000/cu mm.
(b) If there are no signs of end-organ damage or inflammation, clozapine continuation or rechallenge with careful monitoring may be considered.


Source: 
(a) Indian J Psychiatry. 2015 Oct-Dec; 57(4): 429–430.
(b) http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019758s062lbl.pdf

*****************
Click on to post your comments

Admin
Admin
Admin

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

http://psychiatry.find-forum.net

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum