Follow Forum_Psych on Twitter
Search
 
 

Display results as :
 


Rechercher Advanced Search

Statistics
We have 222 registered users
The newest registered user is raheelmemon

Our users have posted a total of 1140 messages in 613 subjects
If you are seeing this, you have attempted to link to the UpToDate widget but are experiencing a problem. Please visit UpToDate for more information.
Share

Imaging Biomarkers for Outcomes in Mild TBI

View previous topic View next topic Go down

Imaging Biomarkers for Outcomes in Mild TBI

Post  Admin on Fri Jul 22, 2016 12:37 pm

Imaging Biomarkers for Outcomes in Mild TBI


Mild traumatic brain injury (mTBI) results in cognitive impairment (memory, attention, and executive function), post-concussion symptoms (PCS) and limitations in daily functioning.

Goal of this prospective longitudinal study: Question  Question  
To identify early diffusion tensor imaging biomarkers of mTBI that significantly relate to outcomes at 1 year following injury.

Methods:
* Diffusion Tensor Imaging (DTI) was performed on 39 subjects with mTBI within 16 days of injury and 40 controls.
* 26 subjects with mTBI returned for follow-up at 1 year: Cognitive function, PCS, and HRQoL (health-related quality of life) were assessed.

Results: Arrow  Arrow

* Significant associations of brain-wide DTI measures and outcomes included the following:
(a) mean radial diffusivity and mean diffusivity with memory; and
(b) mean fractional anisotropy, radial diffusivity, and mean diffusivity with health-related quality of life.

* Significant differences in outcomes were found between subjects with and without abnormally high fractional anisotropy for the following white matter regions and outcome measures:
(a) left frontal lobe and left temporal lobe with attention at 1 year,
(b) left and right cerebelli with somatic postconcussion symptoms at 1 year, and
(c) right thalamus with emotional postconcussion symptoms at 1 year.

Arrow  Arrow Abnormally high fractional anisotropy is significantly associated with better outcomes and might represent an imaging correlate of postinjury compensatory processes.

Source: Strauss SB et al. AJNR Am J Neuroradiol. 2016 Jun 9

*****************
Click on to post your comments
avatar
Admin
Admin
Admin

Posts : 948
Points : 2102
Reputation : 0
Join date : 2011-02-19
Location : Philadelphia

http://psychiatry.find-forum.net

Back to top Go down

View previous topic View next topic Back to top

- Similar topics

 
Permissions in this forum:
You cannot reply to topics in this forum