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Imaging Biomarkers for Outcomes in Mild TBI
Mild traumatic brain injury (mTBI) results in cognitive impairment (memory, attention, and executive function), post-concussion symptoms (PCS) and limitations in daily functioning.
Goal of this prospective longitudinal study:
To identify early diffusion tensor imaging biomarkers of mTBI that significantly relate to outcomes at 1 year following injury.
* Diffusion Tensor Imaging (DTI) was performed on 39 subjects with mTBI within 16 days of injury and 40 controls.
* 26 subjects with mTBI returned for follow-up at 1 year: Cognitive function, PCS, and HRQoL (health-related quality of life) were assessed.
* Significant associations of brain-wide DTI measures and outcomes included the following:
(a) mean radial diffusivity and mean diffusivity with memory; and
(b) mean fractional anisotropy, radial diffusivity, and mean diffusivity with health-related quality of life.
* Significant differences in outcomes were found between subjects with and without abnormally high fractional anisotropy for the following white matter regions and outcome measures:
(a) left frontal lobe and left temporal lobe with attention at 1 year,
(b) left and right cerebelli with somatic postconcussion symptoms at 1 year, and
(c) right thalamus with emotional postconcussion symptoms at 1 year.
Abnormally high fractional anisotropy is significantly associated with better outcomes and might represent an imaging correlate of postinjury compensatory processes.
Source: Strauss SB et al. AJNR Am J Neuroradiol. 2016 Jun 9
Full PDF Available at: http://www.ajnr.org/content/early/2016/06/09/ajnr.A4851.full.pdf+html
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